Assess students' ability to apply Michaelis–Menten kinetics to compute initial reaction rates (v0) and to determine how competitive and noncompetitive inhibitors alter apparent Km and Vmax. Include numeric problems requiring algebraic rearrangement of v = Vmax[S]/(Km+[S]) to calculate v0 given Km, Vmax, [S], and Ki; compute apparent Km' and Vmax' for each inhibitor type; and interpret Lineweaver–Burk or direct plots to justify mechanistic conclusions. Require stepwise calculations and a brief explanation of kinetic implications.