Assess students' ability to apply Michaelis–Menten kinetics to predict and optimize enzyme-catalyzed reaction rates in bioreactor systems; tasks include deriving rate expressions, estimating Vmax and Km from experimental data (linear and nonlinear methods), predicting reactor performance (batch, CSTR, PFR) while accounting for enzyme concentration, inhibition, and mass-transfer or operational constraints, and proposing optimization strategies for feed, immobilization, or reactor configuration.