Assess learners’ ability to evaluate the analytical validity, reproducibility, and clinical utility of somatic variant‑calling pipelines for clinical cancer genomics. Include pipeline components (alignment, preprocessing, somatic callers, filtering, annotation), validation study design (reference standards, synthetic mixes, tumor purity, variant allele fraction, limit of detection), performance metrics (sensitivity, specificity, precision/recall, FDR, confidence intervals), reproducibility practices (versioning, containers, workflow managers, cross‑site concordance), orthogonal confirmation methods, reporting/interpretation standards (AMP/ASCO/CAP), and regulatory/proficiency testing implications. Questions should require designing validation experiments, interpreting performance data, and critically appraising claims about pipeline suitability for clinical decision‑making.