Test graduate-level understanding of how biological, psychological, and social factors influence chronic pain management in adults, covering pathophysiology (neuroplasticity, central sensitization), common comorbidities, psychological processes (catastrophizing, fear‑avoidance, mood, coping), social determinants (support, socioeconomic and cultural factors), assessment strategies, evidence-based multimodal interventions (pharmacologic, CBT, physical rehabilitation, interdisciplinary care), and implications for treatment planning and outcome evaluation.