Evaluate students' ability to design an integrated experimental–computational pipeline to engineer and validate a stochastic noise‑resistant synthetic gene oscillator in mammalian cells: require a proposed circuit topology (components, feedback, insulation), a stochastic modeling plan (master equation, simulation methods, noise sources), parameter inference and identifiability strategies (experimental design, Bayesian/MLE, MCMC/ABC, priors), and validation assays (single‑cell time‑lapse fluorescence, flow cytometry, perturbations) with quantitative metrics (CV, Fano factor, autocorrelation, phase stability). Ask for justification of trade‑offs, experimental feasibility, and biosafety considerations.